藥物交互作用
Amiodarone + Bisoprolol
嚴重程度: 嚴重
Amiodarone and Bisoprolol: major interaction.
最後更新
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摘要
Both drugs slow heart rate and AV conduction, and the combination can cause severe bradycardia, AV block or sinus arrest. Amiodarone's long half-life means the risk persists after discontinuation.
用白話說明這項交互作用的意義
Amiodarone and Bisoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Bisoprolol belongs to Cardiovascular.
為什麼會發生
Additive negative chronotropic and dromotropic effects from beta-blockade and amiodarone's sodium, calcium and potassium channel and beta-blocking actions.
處置方式
Monitor heart rate and ECG, especially at initiation, and reduce the bisoprolol dose or stop one agent if symptomatic bradycardia or conduction block develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bisoprolol 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Bisoprolol?
MediHelp rates the interaction as major. Amiodarone and Bisoprolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow heart rate and AV conduction, and the combination can cause severe bradycardia, AV block or sinus arrest. Amiodarone's long half-life means the risk persists after discontinuation.
How serious is the interaction between Amiodarone and Bisoprolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially at initiation, and reduce the bisoprolol dose or stop one agent if symptomatic bradycardia or conduction block develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Atenolol-chlorthalidone. The full list is on the Bisoprolol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
