藥物交互作用
Amiodarone + Carvedilol
嚴重程度: 嚴重
Amiodarone and Carvedilol: major interaction.
最後更新
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摘要
Amiodarone inhibits CYP2D6 and CYP2C9 and raises carvedilol exposure. Both drugs slow heart rate and AV conduction, so bradycardia, heart block and hypotension may occur.
用白話說明這項交互作用的意義
Amiodarone and Carvedilol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
為什麼會發生
Pharmacokinetic inhibition of carvedilol metabolism plus additive negative chronotropic and dromotropic effects.
處置方式
Monitor ECG and heart rate, particularly at initiation, and start with a low carvedilol dose. Avoid in patients with sinus node dysfunction or conduction disease unless paced.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carvedilol 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Carvedilol?
MediHelp rates the interaction as major. Amiodarone and Carvedilol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP2D6 and CYP2C9 and raises carvedilol exposure. Both drugs slow heart rate and AV conduction, so bradycardia, heart block and hypotension may occur.
How serious is the interaction between Amiodarone and Carvedilol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, particularly at initiation, and start with a low carvedilol dose. Avoid in patients with sinus node dysfunction or conduction disease unless paced.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Albuterol, Amifostine, Arformoterol. The full list is on the Carvedilol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
