藥物交互作用
Amiodarone + Levofloxacin
嚴重程度: 嚴重
Amiodarone and Levofloxacin: major interaction.
最後更新 來源: US FDA label
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摘要
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with bradycardia, hypokalemia, hypomagnesemia, structural heart disease, older age and female sex. Amiodarone's very long half-life means the risk persists for weeks after stopping.
用白話說明這項交互作用的意義
Amiodarone and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Levofloxacin belongs to Anti Bacterial.
為什麼會發生
Pharmacodynamic additive QT prolongation through blockade of the IKr (hERG) potassium current by both drugs.
處置方式
Avoid the combination if possible and choose an antibiotic with less QT effect. If it must be used, obtain a baseline ECG and repeat it after starting, correct potassium and magnesium, and stop other QT-prolonging drugs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Levofloxacin 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Levofloxacin?
MediHelp rates the interaction as major. Amiodarone and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other ventricular arrhythmias. The risk is higher with bradycardia, hypokalemia, hypomagnesemia, structural heart disease, older age and female sex. Amiodarone's very long half-life means the risk persists for weeks after stopping.
How serious is the interaction between Amiodarone and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and choose an antibiotic with less QT effect. If it must be used, obtain a baseline ECG and repeat it after starting, correct potassium and magnesium, and stop other QT-prolonging drugs.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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