藥物交互作用
Amiodarone + Moxifloxacin
嚴重程度: 禁忌併用
Amiodarone and Moxifloxacin: contraindicated interaction.
最後更新
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摘要
Both agents prolong the QT interval, and the combination markedly increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
用白話說明這項交互作用的意義
Amiodarone and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
為什麼會發生
Additive blockade of cardiac potassium channels (IKr) resulting in delayed repolarization.
處置方式
Avoid the combination and choose a non-QT-prolonging antibiotic. If it cannot be avoided, monitor ECG closely and keep potassium and magnesium within normal range.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Moxifloxacin 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Amiodarone and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, and the combination markedly increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
How serious is the interaction between Amiodarone and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibiotic. If it cannot be avoided, monitor ECG closely and keep potassium and magnesium within normal range.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Moxifloxacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
