藥物交互作用
Disopyramide + Moxifloxacin
嚴重程度: 禁忌併用
Disopyramide and Moxifloxacin: contraindicated interaction.
最後更新
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摘要
Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias. Disopyramide is a class Ia antiarrhythmic with notable proarrhythmic potential.
用白話說明這項交互作用的意義
Disopyramide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
為什麼會發生
Additive blockade of cardiac potassium channels (hERG) causing delayed repolarization and QT prolongation.
處置方式
Avoid the combination and choose a non-QT-prolonging antibacterial such as a beta-lactam. If unavoidable, ECG and electrolyte monitoring are essential.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Moxifloxacin 的其他交互作用
Disopyramide 的其他交互作用
常見問題
Can I take Disopyramide with Moxifloxacin?
MediHelp rates the interaction as contraindicated. Disopyramide and Moxifloxacin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias. Disopyramide is a class Ia antiarrhythmic with notable proarrhythmic potential.
How serious is the interaction between Disopyramide and Moxifloxacin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibacterial such as a beta-lactam. If unavoidable, ECG and electrolyte monitoring are essential.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Dofetilide. The full list is on the Moxifloxacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
