藥物交互作用
Amiodarone + Nadolol
嚴重程度: 嚴重
Amiodarone and Nadolol: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs slow the sinus rate and AV conduction, so combined use may cause symptomatic bradycardia, AV block or hypotension. The risk is highest in older patients or those with conduction disease or heart failure.
用白話說明這項交互作用的意義
Amiodarone and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
為什麼會發生
Additive negative chronotropic and dromotropic effects through beta blockade and amiodarone's channel and adrenergic effects.
處置方式
Monitor heart rate, blood pressure and ECG, especially after initiation or dose increases. Reduce the nadolol dose or stop one drug if significant bradycardia or block develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Nadolol 的其他交互作用
常見問題
Can I take Amiodarone with Nadolol?
MediHelp rates the interaction as major. Amiodarone and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow the sinus rate and AV conduction, so combined use may cause symptomatic bradycardia, AV block or hypotension. The risk is highest in older patients or those with conduction disease or heart failure.
How serious is the interaction between Amiodarone and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, especially after initiation or dose increases. Reduce the nadolol dose or stop one drug if significant bradycardia or block develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
