藥物交互作用
Amiodarone + Ponesimod
嚴重程度: 嚴重
Amiodarone and Ponesimod: major interaction.
最後更新
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摘要
Ponesimod slows heart rate and can affect AV conduction, and amiodarone is a class III antiarrhythmic with QT-prolonging and bradycardic effects. Together they raise the risk of serious bradycardia and torsades de pointes.
用白話說明這項交互作用的意義
Amiodarone and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Ponesimod belongs to Central Nervous System.
為什麼會發生
Additive bradycardia and conduction slowing, with amiodarone's QT prolongation.
處置方式
Avoid starting ponesimod in patients on amiodarone unless a cardiologist has assessed the risk. If used, obtain a baseline ECG and monitor heart rate and rhythm.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Ponesimod 的其他交互作用
常見問題
Can I take Amiodarone with Ponesimod?
MediHelp rates the interaction as major. Amiodarone and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponesimod slows heart rate and can affect AV conduction, and amiodarone is a class III antiarrhythmic with QT-prolonging and bradycardic effects. Together they raise the risk of serious bradycardia and torsades de pointes.
How serious is the interaction between Amiodarone and Ponesimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ponesimod in patients on amiodarone unless a cardiologist has assessed the risk. If used, obtain a baseline ECG and monitor heart rate and rhythm.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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