藥物交互作用
Eplerenone + Ritonavir
嚴重程度: 禁忌併用
Eplerenone and Ritonavir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ritonavir is a strong CYP3A4 inhibitor and markedly increases eplerenone exposure. This raises the risk of dangerous hyperkalemia, and strong CYP3A4 inhibitors are contraindicated with eplerenone in labeling.
用白話說明這項交互作用的意義
Eplerenone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eplerenone belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
為什麼會發生
Ritonavir strongly inhibits CYP3A4, blocking the main metabolic pathway of eplerenone.
處置方式
Do not combine; use an alternative antiretroviral or a different mineralocorticoid antagonist strategy. If exposure occurs, monitor potassium closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eplerenone 的其他交互作用
Ritonavir 的其他交互作用
常見問題
Can I take Eplerenone with Ritonavir?
MediHelp rates the interaction as contraindicated. Eplerenone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir is a strong CYP3A4 inhibitor and markedly increases eplerenone exposure. This raises the risk of dangerous hyperkalemia, and strong CYP3A4 inhibitors are contraindicated with eplerenone in labeling.
How serious is the interaction between Eplerenone and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative antiretroviral or a different mineralocorticoid antagonist strategy. If exposure occurs, monitor potassium closely.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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