藥物交互作用
Amisulpride + Atomoxetine
嚴重程度: 嚴重
Amisulpride and Atomoxetine: major interaction.
最後更新
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摘要
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease. Amisulpride has a clear dose-related QT effect.
用白話說明這項交互作用的意義
Amisulpride and Atomoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Atomoxetine belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation, with amisulpride blocking cardiac hERG potassium channels and atomoxetine having a smaller effect.
處置方式
Avoid if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atomoxetine 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amisulpride with Atomoxetine?
MediHelp rates the interaction as major. Amisulpride and Atomoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease. Amisulpride has a clear dose-related QT effect.
How serious is the interaction between Amisulpride and Atomoxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy.
What other medicines interact with Atomoxetine?
MediHelp also lists interactions of Atomoxetine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Atomoxetine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
