藥物交互作用
Amisulpride + Disopyramide
嚴重程度: 禁忌併用
Amisulpride and Disopyramide: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Disopyramide is a class Ia antiarrhythmic that prolongs the QT interval and has caused torsades de pointes. Amisulpride adds further QT prolongation, so the combination markedly increases proarrhythmic risk.
用白話說明這項交互作用的意義
Amisulpride and Disopyramide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Disopyramide belongs to Cardiovascular.
為什麼會發生
Additive QT prolongation through potassium channel blockade.
處置方式
Avoid the combination and select an antipsychotic or antiarrhythmic with lower QT risk. If unavoidable, monitor the ECG closely and correct potassium and magnesium.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amisulpride 的其他交互作用
Disopyramide 的其他交互作用
常見問題
Can I take Amisulpride with Disopyramide?
MediHelp rates the interaction as contraindicated. Amisulpride and Disopyramide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide is a class Ia antiarrhythmic that prolongs the QT interval and has caused torsades de pointes. Amisulpride adds further QT prolongation, so the combination markedly increases proarrhythmic risk.
How serious is the interaction between Amisulpride and Disopyramide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antipsychotic or antiarrhythmic with lower QT risk. If unavoidable, monitor the ECG closely and correct potassium and magnesium.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Dofetilide. The full list is on the Amisulpride page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
