藥物交互作用
Amitriptyline + Trospium
嚴重程度: 中度
Amitriptyline and Trospium: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amitriptyline is strongly anticholinergic and combined with trospium increases the antimuscarinic burden. This may cause urinary retention, constipation, dry mouth, tachycardia and confusion.
用白話說明這項交互作用的意義
Amitriptyline and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Trospium belongs to Genitourinary.
為什麼會發生
Additive antimuscarinic pharmacodynamic effects.
處置方式
Monitor for anticholinergic toxicity, especially in elderly patients. Consider a less anticholinergic antidepressant if symptoms occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Trospium 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Trospium?
MediHelp rates the interaction as moderate. Amitriptyline and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline is strongly anticholinergic and combined with trospium increases the antimuscarinic burden. This may cause urinary retention, constipation, dry mouth, tachycardia and confusion.
How serious is the interaction between Amitriptyline and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in elderly patients. Consider a less anticholinergic antidepressant if symptoms occur.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
