藥物交互作用
Amlodipine-atorvastatin + Cyclosporine
嚴重程度: 嚴重
Amlodipine-atorvastatin and Cyclosporine: major interaction.
最後更新
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摘要
Cyclosporine raises atorvastatin exposure markedly through OATP1B1 and CYP3A4 inhibition, increasing the risk of myopathy and rhabdomyolysis, and may also raise amlodipine levels. Amlodipine can modestly increase cyclosporine trough concentrations.
用白話說明這項交互作用的意義
Amlodipine-atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cyclosporine inhibits CYP3A4 and OATP1B1, and amlodipine may modestly raise cyclosporine levels through CYP3A4/P-gp effects.
處置方式
Avoid atorvastatin with cyclosporine, as labeling advises, and use an alternative statin at a restricted dose; monitor cyclosporine trough levels and blood pressure if amlodipine is used.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-atorvastatin 的其他交互作用
常見問題
Can I take Amlodipine-atorvastatin with Cyclosporine?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises atorvastatin exposure markedly through OATP1B1 and CYP3A4 inhibition, increasing the risk of myopathy and rhabdomyolysis, and may also raise amlodipine levels. Amlodipine can modestly increase cyclosporine trough concentrations.
How serious is the interaction between Amlodipine-atorvastatin and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid atorvastatin with cyclosporine, as labeling advises, and use an alternative statin at a restricted dose; monitor cyclosporine trough levels and blood pressure if amlodipine is used.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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