藥物交互作用
Amlodipine-atorvastatin + Danazol
嚴重程度: 嚴重
Amlodipine-atorvastatin and Danazol: major interaction.
最後更新
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摘要
Danazol inhibits CYP3A4 and may raise atorvastatin and amlodipine concentrations. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis, and amlodipine excess may cause hypotension or edema.
用白話說明這項交互作用的意義
Amlodipine-atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Danazol inhibits CYP3A4, decreasing metabolism of amlodipine and atorvastatin.
處置方式
Avoid the combination where possible, or use the lowest effective statin dose and monitor for muscle symptoms, CK and blood pressure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-atorvastatin 的其他交互作用
常見問題
Can I take Amlodipine-atorvastatin with Danazol?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Danazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Danazol inhibits CYP3A4 and may raise atorvastatin and amlodipine concentrations. Increased atorvastatin exposure raises the risk of myopathy and rhabdomyolysis, and amlodipine excess may cause hypotension or edema.
How serious is the interaction between Amlodipine-atorvastatin and Danazol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest effective statin dose and monitor for muscle symptoms, CK and blood pressure.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
