藥物交互作用
Amlodipine-atorvastatin + Clarithromycin
嚴重程度: 嚴重
Amlodipine-atorvastatin and Clarithromycin: major interaction.
最後更新
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摘要
Clarithromycin strongly inhibits CYP3A4, raising amlodipine and atorvastatin concentrations. This increases the risk of hypotension, edema and acute kidney injury, and of statin-related myopathy or rhabdomyolysis.
用白話說明這項交互作用的意義
Amlodipine-atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
為什麼會發生
Clarithromycin inhibits CYP3A4 (and P-glycoprotein), reducing metabolism of amlodipine and atorvastatin.
處置方式
Avoid the combination if possible by using a non-interacting antibiotic such as azithromycin, or suspend atorvastatin during the course. If used, limit the atorvastatin dose and monitor blood pressure and muscle symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-atorvastatin 的其他交互作用
Clarithromycin 的其他交互作用
常見問題
Can I take Amlodipine-atorvastatin with Clarithromycin?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin strongly inhibits CYP3A4, raising amlodipine and atorvastatin concentrations. This increases the risk of hypotension, edema and acute kidney injury, and of statin-related myopathy or rhabdomyolysis.
How serious is the interaction between Amlodipine-atorvastatin and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible by using a non-interacting antibiotic such as azithromycin, or suspend atorvastatin during the course. If used, limit the atorvastatin dose and monitor blood pressure and muscle symptoms.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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