藥物交互作用
Amobarbital + Azelastine-fluticasone
嚴重程度: 中度
Amobarbital and Azelastine-fluticasone: moderate interaction.
最後更新
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摘要
Amobarbital is a barbiturate that causes marked CNS depression, and azelastine can add drowsiness. Barbiturates also induce CYP3A4 and may reduce fluticasone exposure.
用白話說明這項交互作用的意義
Amobarbital and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
為什麼會發生
Additive CNS depression from H1 antagonism and barbiturate GABA-A potentiation, with CYP3A4 induction.
處置方式
Counsel on sedation and avoid alcohol and driving. Use the lowest effective doses and monitor for excessive drowsiness.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azelastine-fluticasone 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Azelastine-fluticasone?
MediHelp rates the interaction as moderate. Amobarbital and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital is a barbiturate that causes marked CNS depression, and azelastine can add drowsiness. Barbiturates also induce CYP3A4 and may reduce fluticasone exposure.
How serious is the interaction between Amobarbital and Azelastine-fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and avoid alcohol and driving. Use the lowest effective doses and monitor for excessive drowsiness.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
