藥物交互作用
Amitriptyline + Azelastine-fluticasone
嚴重程度: 中度
Amitriptyline and Azelastine-fluticasone: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both azelastine and amitriptyline have sedating antihistaminic properties, so combined use can increase drowsiness and impair alertness. Amitriptyline also adds anticholinergic effects.
用白話說明這項交互作用的意義
Amitriptyline and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Azelastine-fluticasone belongs to Respiratory.
為什麼會發生
Additive CNS depression through histamine H1 blockade.
處置方式
Warn patients about drowsiness and avoid driving until tolerance is clear. Consider dose reduction or a nonsedating alternative if sedation is troublesome.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Azelastine-fluticasone 的其他交互作用
Amitriptyline 的其他交互作用
常見問題
Can I take Amitriptyline with Azelastine-fluticasone?
MediHelp rates the interaction as moderate. Amitriptyline and Azelastine-fluticasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both azelastine and amitriptyline have sedating antihistaminic properties, so combined use can increase drowsiness and impair alertness. Amitriptyline also adds anticholinergic effects.
How serious is the interaction between Amitriptyline and Azelastine-fluticasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and avoid driving until tolerance is clear. Consider dose reduction or a nonsedating alternative if sedation is troublesome.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
