Drug interactions
Amobarbital + Calcifediol
Severity: Moderate
Amobarbital and Calcifediol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can accelerate vitamin D metabolism and lower circulating calcifediol, and long-term use is associated with reduced bone mineral density and osteomalacia.
What this interaction means in plain words
Amobarbital and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Calcifediol belongs to Musculoskeletal.
Why it happens
Induction of hepatic CYP enzymes (including CYP3A4) increases catabolism of vitamin D metabolites.
What to do
Monitor serum 25-hydroxyvitamin D, calcium and parathyroid hormone and increase the vitamin D dose if levels fall. Reassess bone health during prolonged barbiturate therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amobarbital and Calcifediol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
- Calcifediol + Captopril-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Amobarbital with Calcifediol?
MediHelp rates the interaction as moderate. Amobarbital and Calcifediol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can accelerate vitamin D metabolism and lower circulating calcifediol, and long-term use is associated with reduced bone mineral density and osteomalacia.
How serious is the interaction between Amobarbital and Calcifediol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, calcium and parathyroid hormone and increase the vitamin D dose if levels fall. Reassess bone health during prolonged barbiturate therapy.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
