藥物交互作用
Amoxapine + Formoterol
嚴重程度: 嚴重
Amoxapine and Formoterol: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Amoxapine, a tricyclic-like antidepressant, can prolong the QT interval and may potentiate the cardiovascular effects of formoterol. Together they raise the risk of arrhythmia, especially with hypokalemia or heart disease.
用白話說明這項交互作用的意義
Amoxapine and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive QT prolongation plus tricyclic potentiation of adrenergic cardiovascular effects via noradrenaline reuptake inhibition.
處置方式
Formoterol labeling advises extreme caution with tricyclics; monitor ECG and potassium, and consider an alternative antidepressant or bronchodilator in patients with QT risk factors.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Formoterol 的其他交互作用
常見問題
Can I take Amoxapine with Formoterol?
MediHelp rates the interaction as major. Amoxapine and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amoxapine, a tricyclic-like antidepressant, can prolong the QT interval and may potentiate the cardiovascular effects of formoterol. Together they raise the risk of arrhythmia, especially with hypokalemia or heart disease.
How serious is the interaction between Amoxapine and Formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Formoterol labeling advises extreme caution with tricyclics; monitor ECG and potassium, and consider an alternative antidepressant or bronchodilator in patients with QT risk factors.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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