藥物交互作用
Amiodarone + Formoterol
嚴重程度: 嚴重
Amiodarone and Formoterol: major interaction.
最後更新
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摘要
Amiodarone markedly prolongs the QT interval and formoterol can add to this through hypokalemia and sympathetic stimulation, raising the risk of torsades de pointes. The risk is higher with high doses, hypokalemia or structural heart disease.
用白話說明這項交互作用的意義
Amiodarone and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Formoterol belongs to Respiratory.
為什麼會發生
Additive QT prolongation, with beta-2 agonist induced hypokalemia and tachycardia worsening repolarization instability.
處置方式
Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during co-use. Use the lowest effective formoterol dose and keep electrolytes normal.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Formoterol 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Formoterol?
MediHelp rates the interaction as major. Amiodarone and Formoterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval and formoterol can add to this through hypokalemia and sympathetic stimulation, raising the risk of torsades de pointes. The risk is higher with high doses, hypokalemia or structural heart disease.
How serious is the interaction between Amiodarone and Formoterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during co-use. Use the lowest effective formoterol dose and keep electrolytes normal.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amisulpride, Amitriptyline. The full list is on the Formoterol page.
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