藥物交互作用
Amoxapine + Trihexyphenidyl
嚴重程度: 中度
Amoxapine and Trihexyphenidyl: moderate interaction.
最後更新
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摘要
Amoxapine, a tricyclic-type antidepressant, has anticholinergic activity that adds to trihexyphenidyl. This increases the risk of urinary retention, constipation, tachycardia, blurred vision and confusion, especially in older adults.
用白話說明這項交互作用的意義
Amoxapine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive muscarinic antagonism.
處置方式
Monitor for central and peripheral anticholinergic toxicity and use the lowest effective doses. Consider a less anticholinergic antidepressant if toxicity develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Trihexyphenidyl 的其他交互作用
常見問題
Can I take Amoxapine with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Amoxapine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amoxapine, a tricyclic-type antidepressant, has anticholinergic activity that adds to trihexyphenidyl. This increases the risk of urinary retention, constipation, tachycardia, blurred vision and confusion, especially in older adults.
How serious is the interaction between Amoxapine and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for central and peripheral anticholinergic toxicity and use the lowest effective doses. Consider a less anticholinergic antidepressant if toxicity develops.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
