藥物交互作用
Solifenacin + Trihexyphenidyl
嚴重程度: 嚴重
Solifenacin and Trihexyphenidyl: major interaction.
最後更新
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摘要
Both drugs are antimuscarinic, so combined use can produce marked dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are especially vulnerable to cognitive impairment and delirium.
用白話說明這項交互作用的意義
Solifenacin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Solifenacin belongs to Genitourinary; Trihexyphenidyl belongs to Central Nervous System.
為什麼會發生
Additive antagonism of muscarinic receptors.
處置方式
Avoid the combination where possible, particularly in older adults. If necessary, use the lowest effective doses and monitor for urinary retention, constipation and cognitive changes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Solifenacin 的其他交互作用
Trihexyphenidyl 的其他交互作用
常見問題
Can I take Solifenacin with Trihexyphenidyl?
MediHelp rates the interaction as major. Solifenacin and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are antimuscarinic, so combined use can produce marked dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Older adults are especially vulnerable to cognitive impairment and delirium.
How serious is the interaction between Solifenacin and Trihexyphenidyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in older adults. If necessary, use the lowest effective doses and monitor for urinary retention, constipation and cognitive changes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
