藥物交互作用
Scopolamine + Trihexyphenidyl
嚴重程度: 嚴重
Scopolamine and Trihexyphenidyl: major interaction.
最後更新
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摘要
Both are potent antimuscarinics, so combining them can produce marked anticholinergic toxicity with dry mouth, constipation, urinary retention, blurred vision, tachycardia, confusion and hallucinations. Older adults are especially susceptible, and hyperthermia can occur.
用白話說明這項交互作用的意義
Scopolamine and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Scopolamine belongs to Respiratory; Trihexyphenidyl belongs to Central Nervous System.
為什麼會發生
Additive muscarinic receptor blockade in the central and peripheral nervous systems.
處置方式
Avoid the combination where possible, particularly in older adults. If it is necessary, use the lowest doses and monitor for delirium, retention and tachycardia.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Scopolamine 的其他交互作用
Trihexyphenidyl 的其他交互作用
常見問題
Can I take Scopolamine with Trihexyphenidyl?
MediHelp rates the interaction as major. Scopolamine and Trihexyphenidyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are potent antimuscarinics, so combining them can produce marked anticholinergic toxicity with dry mouth, constipation, urinary retention, blurred vision, tachycardia, confusion and hallucinations. Older adults are especially susceptible, and hyperthermia can occur.
How serious is the interaction between Scopolamine and Trihexyphenidyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in older adults. If it is necessary, use the lowest doses and monitor for delirium, retention and tachycardia.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
