藥物交互作用
Amoxicillin-clavulanic acid + Cholera vaccine
嚴重程度: 中度
Amoxicillin-clavulanic acid and Cholera vaccine: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
The oral live attenuated cholera vaccine relies on the vaccine strain colonizing the gut. Systemic antibiotics with activity against it may kill the strain and impair the immune response. Amoxicillin-clavulanate has activity against many Vibrio strains, so vaccine effectiveness could be reduced.
用白話說明這項交互作用的意義
Amoxicillin-clavulanic acid and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Antibacterial activity against the live attenuated Vibrio cholerae vaccine strain reduces its replication and immunogenicity.
處置方式
Do not give the vaccine to patients who have taken systemic antibiotics in the preceding 14 days, per labeling. Avoid starting antibiotics for about 10 days after vaccination where possible, or revaccinate after the antibiotic course.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amoxicillin-clavulanic acid 的其他交互作用
常見問題
Can I take Amoxicillin-clavulanic acid with Cholera vaccine?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine relies on the vaccine strain colonizing the gut. Systemic antibiotics with activity against it may kill the strain and impair the immune response. Amoxicillin-clavulanate has activity against many Vibrio strains, so vaccine effectiveness could be reduced.
How serious is the interaction between Amoxicillin-clavulanic acid and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have taken systemic antibiotics in the preceding 14 days, per labeling. Avoid starting antibiotics for about 10 days after vaccination where possible, or revaccinate after the antibiotic course.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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