藥物交互作用
Amoxicillin-clavulanic acid + Chloramphenicol
嚴重程度: 中度
Amoxicillin-clavulanic acid and Chloramphenicol: moderate interaction.
最後更新
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摘要
Chloramphenicol is bacteriostatic and may reduce the bactericidal effect of amoxicillin in vitro. The clinical relevance is uncertain but could matter in severe infections.
用白話說明這項交互作用的意義
Amoxicillin-clavulanic acid and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
為什麼會發生
Pharmacodynamic antagonism, as inhibition of bacterial protein synthesis may reduce cell-wall-dependent killing by the beta-lactam.
處置方式
Avoid combining them in serious infections requiring bactericidal therapy and use a single appropriate agent where possible. If both are used, monitor clinical response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amoxicillin-clavulanic acid 的其他交互作用
Chloramphenicol 的其他交互作用
常見問題
Can I take Amoxicillin-clavulanic acid with Chloramphenicol?
MediHelp rates the interaction as moderate. Amoxicillin-clavulanic acid and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the bactericidal effect of amoxicillin in vitro. The clinical relevance is uncertain but could matter in severe infections.
How serious is the interaction between Amoxicillin-clavulanic acid and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them in serious infections requiring bactericidal therapy and use a single appropriate agent where possible. If both are used, monitor clinical response.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Methotrexate, Pexidartinib, Pretomanid. The full list is on the Amoxicillin-clavulanic acid page.
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