藥物交互作用
Amoxicillin-clavulanic acid + Methotrexate
嚴重程度: 嚴重
Amoxicillin-clavulanic acid and Methotrexate: major interaction.
最後更新
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摘要
Penicillins can raise methotrexate concentrations and prolong exposure, leading to increased myelosuppression, mucositis and other toxicity. The effect is most concerning with high-dose methotrexate or impaired renal function.
用白話說明這項交互作用的意義
Amoxicillin-clavulanic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amoxicillin-clavulanic acid belongs to Anti Bacterial; Methotrexate belongs to Oncology.
為什麼會發生
Competition for renal tubular secretion reduces methotrexate renal clearance.
處置方式
Monitor methotrexate levels, renal function and blood counts when co-administered, and consider an alternative antibiotic during high-dose methotrexate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amoxicillin-clavulanic acid 的其他交互作用
Methotrexate 的其他交互作用
常見問題
Can I take Amoxicillin-clavulanic acid with Methotrexate?
MediHelp rates the interaction as major. Amoxicillin-clavulanic acid and Methotrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penicillins can raise methotrexate concentrations and prolong exposure, leading to increased myelosuppression, mucositis and other toxicity. The effect is most concerning with high-dose methotrexate or impaired renal function.
How serious is the interaction between Amoxicillin-clavulanic acid and Methotrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor methotrexate levels, renal function and blood counts when co-administered, and consider an alternative antibiotic during high-dose methotrexate.
What other medicines interact with Amoxicillin-clavulanic acid?
MediHelp also lists interactions of Amoxicillin-clavulanic acid with, for example, Pexidartinib, Pretomanid, Allopurinol. The full list is on the Amoxicillin-clavulanic acid page.
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在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
