藥物交互作用
Amphotericin b deoxycholate + Gentamicin
嚴重程度: 嚴重
Amphotericin b deoxycholate and Gentamicin: major interaction.
最後更新
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摘要
Both agents damage renal tubules, and together they commonly produce acute kidney injury and electrolyte loss. Impaired renal clearance may raise gentamicin levels and ototoxicity risk.
用白話說明這項交互作用的意義
Amphotericin b deoxycholate and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive nephrotoxicity from tubular injury and amphotericin-induced renal vasoconstriction.
處置方式
Avoid concurrent use if alternatives exist, such as a lipid amphotericin formulation or another antibiotic. If necessary, monitor creatinine, potassium, magnesium and gentamicin levels.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Gentamicin 的其他交互作用
常見問題
Can I take Amphotericin b deoxycholate with Gentamicin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents damage renal tubules, and together they commonly produce acute kidney injury and electrolyte loss. Impaired renal clearance may raise gentamicin levels and ototoxicity risk.
How serious is the interaction between Amphotericin b deoxycholate and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist, such as a lipid amphotericin formulation or another antibiotic. If necessary, monitor creatinine, potassium, magnesium and gentamicin levels.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
