藥物交互作用
Atracurium + Gentamicin
嚴重程度: 嚴重
Atracurium and Gentamicin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Gentamicin has neuromuscular blocking activity that potentiates nondepolarising blockers. This can prolong paralysis and cause respiratory depression or apnoea.
用白話說明這項交互作用的意義
Atracurium and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atracurium belongs to Musculoskeletal; Gentamicin belongs to Anti Bacterial.
為什麼會發生
Aminoglycoside inhibition of presynaptic acetylcholine release and reduced postsynaptic sensitivity, additive to atracurium.
處置方式
Monitor train-of-four and reduce atracurium doses as needed. Ensure ventilatory support and complete recovery before extubation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atracurium 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Atracurium with Gentamicin?
MediHelp rates the interaction as major. Atracurium and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gentamicin has neuromuscular blocking activity that potentiates nondepolarising blockers. This can prolong paralysis and cause respiratory depression or apnoea.
How serious is the interaction between Atracurium and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor train-of-four and reduce atracurium doses as needed. Ensure ventilatory support and complete recovery before extubation.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
