藥物交互作用
Amphotericin b + Gentamicin
嚴重程度: 嚴重
Amphotericin b and Gentamicin: major interaction.
最後更新
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摘要
Both drugs cause nephrotoxicity, and gentamicin also carries ototoxic and vestibulotoxic risk. Concurrent use increases the likelihood of acute kidney injury, which in turn raises aminoglycoside levels and further toxicity.
用白話說明這項交互作用的意義
Amphotericin b and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Gentamicin belongs to Anti Bacterial.
為什麼會發生
Additive proximal tubular nephrotoxicity, with accumulation of gentamicin when renal function falls.
處置方式
Avoid the combination if alternatives exist. If needed, monitor creatinine and gentamicin levels closely, hydrate, and consider audiometry for prolonged courses.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amphotericin b 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Amphotericin b with Gentamicin?
MediHelp rates the interaction as major. Amphotericin b and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause nephrotoxicity, and gentamicin also carries ototoxic and vestibulotoxic risk. Concurrent use increases the likelihood of acute kidney injury, which in turn raises aminoglycoside levels and further toxicity.
How serious is the interaction between Amphotericin b and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if alternatives exist. If needed, monitor creatinine and gentamicin levels closely, hydrate, and consider audiometry for prolonged courses.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
