藥物交互作用
Apalutamide + Febuxostat
嚴重程度: 中度
Apalutamide and Febuxostat: moderate interaction.
最後更新
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摘要
Apalutamide induces UGT enzymes and CYP enzymes, which may lower febuxostat concentrations since febuxostat is cleared partly by glucuronidation and CYP oxidation. This could reduce urate-lowering efficacy.
用白話說明這項交互作用的意義
Apalutamide and Febuxostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Febuxostat belongs to Genitourinary.
為什麼會發生
Induction of UGT and CYP enzymes by apalutamide increases febuxostat clearance.
處置方式
Monitor serum uric acid after starting apalutamide and increase the febuxostat dose within labeled limits if the target is not reached.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Febuxostat 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Febuxostat?
MediHelp rates the interaction as moderate. Apalutamide and Febuxostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces UGT enzymes and CYP enzymes, which may lower febuxostat concentrations since febuxostat is cleared partly by glucuronidation and CYP oxidation. This could reduce urate-lowering efficacy.
How serious is the interaction between Apalutamide and Febuxostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid after starting apalutamide and increase the febuxostat dose within labeled limits if the target is not reached.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Azathioprine, Mercaptopurine, Didanosine. The full list is on the Febuxostat page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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