藥物交互作用
Apalutamide + Linagliptin-metformin
嚴重程度: 嚴重
Apalutamide and Linagliptin-metformin: major interaction.
最後更新
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摘要
Apalutamide is a strong CYP3A4 and P-gp inducer and can substantially lower linagliptin levels. The glucose-lowering effect of linagliptin may be lost.
用白話說明這項交互作用的意義
Apalutamide and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Linagliptin-metformin belongs to Endocrine.
為什麼會發生
Strong induction of CYP3A4 and P-glycoprotein increases linagliptin elimination.
處置方式
Monitor glucose closely and consider switching to a DPP-4 inhibitor or other agent not affected by induction. Adjust therapy according to glycemic response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Linagliptin-metformin 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Linagliptin-metformin?
MediHelp rates the interaction as major. Apalutamide and Linagliptin-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 and P-gp inducer and can substantially lower linagliptin levels. The glucose-lowering effect of linagliptin may be lost.
How serious is the interaction between Apalutamide and Linagliptin-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and consider switching to a DPP-4 inhibitor or other agent not affected by induction. Adjust therapy according to glycemic response.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Carbamazepine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Linagliptin-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
