藥物交互作用
Dabigatran etexilate + Defibrotide
嚴重程度: 禁忌併用
Dabigatran etexilate and Defibrotide: contraindicated interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Defibrotide has profibrinolytic activity and may enhance the bleeding risk of anticoagulants. Together with dabigatran this can cause serious hemorrhage.
用白話說明這項交互作用的意義
Dabigatran etexilate and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dabigatran etexilate belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic effects on hemostasis from thrombin inhibition and enhanced fibrinolysis.
處置方式
Avoid concurrent use; hold dabigatran during defibrotide therapy as directed by the specialist team, considering renal function for washout timing.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dabigatran etexilate 的其他交互作用
Defibrotide 的其他交互作用
常見問題
Can I take Dabigatran etexilate with Defibrotide?
MediHelp rates the interaction as contraindicated. Dabigatran etexilate and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic activity and may enhance the bleeding risk of anticoagulants. Together with dabigatran this can cause serious hemorrhage.
How serious is the interaction between Dabigatran etexilate and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold dabigatran during defibrotide therapy as directed by the specialist team, considering renal function for washout timing.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Dabigatran etexilate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
