藥物交互作用
Apixaban + Fondaparinux
嚴重程度: 嚴重
Apixaban and Fondaparinux: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Fondaparinux (a factor Xa-directed indirect inhibitor) and apixaban (a direct factor Xa inhibitor) both suppress thrombin generation or activity, so giving them together amounts to duplicate anticoagulation. The likelihood of serious bleeding rises without added therapeutic benefit.
用白話說明這項交互作用的意義
Apixaban and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Fondaparinux belongs to Cardiovascular.
為什麼會發生
Duplicate anticoagulation at the coagulation cascade
處置方式
Avoid overlapping anticoagulants; when switching, start the new agent at the time the next dose of the old one is due, and monitor for bleeding.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fondaparinux 的其他交互作用
Apixaban 的其他交互作用
常見問題
Can I take Apixaban with Fondaparinux?
MediHelp rates the interaction as major. Apixaban and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fondaparinux (a factor Xa-directed indirect inhibitor) and apixaban (a direct factor Xa inhibitor) both suppress thrombin generation or activity, so giving them together amounts to duplicate anticoagulation. The likelihood of serious bleeding rises without added therapeutic benefit.
How serious is the interaction between Apixaban and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid overlapping anticoagulants; when switching, start the new agent at the time the next dose of the old one is due, and monitor for bleeding.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
