藥物交互作用
Apomorphine + Lofexidine
嚴重程度: 嚴重
Apomorphine and Lofexidine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Both drugs can prolong the QT interval, raising the risk of torsades de pointes. Apomorphine and lofexidine also both cause hypotension and orthostatic symptoms, which compound the risk.
用白話說明這項交互作用的意義
Apomorphine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apomorphine belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation and additive hypotensive effects.
處置方式
Avoid if alternatives exist. Otherwise obtain a baseline ECG, correct electrolytes, and monitor QTc and blood pressure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lofexidine 的其他交互作用
Apomorphine 的其他交互作用
常見問題
Can I take Apomorphine with Lofexidine?
MediHelp rates the interaction as major. Apomorphine and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, raising the risk of torsades de pointes. Apomorphine and lofexidine also both cause hypotension and orthostatic symptoms, which compound the risk.
How serious is the interaction between Apomorphine and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist. Otherwise obtain a baseline ECG, correct electrolytes, and monitor QTc and blood pressure.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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