藥物交互作用
Arsenic trioxide + Lofexidine
嚴重程度: 嚴重
Arsenic trioxide and Lofexidine: major interaction.
最後更新
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摘要
Arsenic trioxide markedly prolongs the QT interval and has caused torsade de pointes. Lofexidine adds further QT prolongation and bradycardia, increasing risk of life-threatening arrhythmia.
用白話說明這項交互作用的意義
Arsenic trioxide and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Lofexidine belongs to Central Nervous System.
為什麼會發生
Additive prolongation of cardiac repolarization.
處置方式
Avoid if possible; otherwise perform ECG monitoring and keep potassium and magnesium within normal range.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lofexidine 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Lofexidine?
MediHelp rates the interaction as major. Arsenic trioxide and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and has caused torsade de pointes. Lofexidine adds further QT prolongation and bradycardia, increasing risk of life-threatening arrhythmia.
How serious is the interaction between Arsenic trioxide and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise perform ECG monitoring and keep potassium and magnesium within normal range.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
