藥物交互作用
Amisulpride + Lofexidine
嚴重程度: 嚴重
Amisulpride and Lofexidine: major interaction.
最後更新
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摘要
Both drugs can prolong the QT interval, and lofexidine also causes bradycardia, which adds to proarrhythmic risk. Together they increase the chance of torsades de pointes.
用白話說明這項交互作用的意義
Amisulpride and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Lofexidine belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation, aggravated by lofexidine-induced bradycardia.
處置方式
Avoid if possible. If co-administered, obtain ECG monitoring, correct potassium and magnesium, and monitor heart rate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lofexidine 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amisulpride with Lofexidine?
MediHelp rates the interaction as major. Amisulpride and Lofexidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and lofexidine also causes bradycardia, which adds to proarrhythmic risk. Together they increase the chance of torsades de pointes.
How serious is the interaction between Amisulpride and Lofexidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If co-administered, obtain ECG monitoring, correct potassium and magnesium, and monitor heart rate.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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