藥物交互作用
Aprepitant + Bexarotene
嚴重程度: 中度
Aprepitant and Bexarotene: moderate interaction.
最後更新
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摘要
Bexarotene is metabolized by CYP3A4, so aprepitant may alter its concentrations. Higher levels could worsen hypertriglyceridemia, hypothyroidism and other adverse effects.
用白話說明這項交互作用的意義
Aprepitant and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Bexarotene belongs to Oncology.
為什麼會發生
Aprepitant inhibits CYP3A4, reducing bexarotene metabolism.
處置方式
Monitor lipids, thyroid function and bexarotene adverse effects when aprepitant is used repeatedly. Adjust the bexarotene dose if toxicity appears.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Aprepitant 的其他交互作用
Bexarotene 的其他交互作用
常見問題
Can I take Aprepitant with Bexarotene?
MediHelp rates the interaction as moderate. Aprepitant and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene is metabolized by CYP3A4, so aprepitant may alter its concentrations. Higher levels could worsen hypertriglyceridemia, hypothyroidism and other adverse effects.
How serious is the interaction between Aprepitant and Bexarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipids, thyroid function and bexarotene adverse effects when aprepitant is used repeatedly. Adjust the bexarotene dose if toxicity appears.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
