藥物交互作用
Bexarotene + Gemfibrozil
嚴重程度: 嚴重
Bexarotene and Gemfibrozil: major interaction.
最後更新
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摘要
Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.
用白話說明這項交互作用的意義
Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bexarotene belongs to Oncology; Gemfibrozil belongs to Cardiovascular.
為什麼會發生
Proposed inhibition of CYP3A4-mediated and possibly other metabolic clearance of bexarotene by gemfibrozil; the mechanism is not firmly established.
處置方式
Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Gemfibrozil 的其他交互作用
Bexarotene 的其他交互作用
常見問題
Can I take Bexarotene with Gemfibrozil?
MediHelp rates the interaction as major. Bexarotene and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil has been associated with markedly raised bexarotene plasma concentrations in a labeling-described observation. Higher bexarotene exposure may worsen its dose-related toxicities such as hypertriglyceridemia, hypothyroidism and pancreatitis.
How serious is the interaction between Bexarotene and Gemfibrozil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; bexarotene labeling advises against it. If unavoidable, monitor lipids, triglycerides and pancreatitis symptoms closely.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
