藥物交互作用
Aripiprazole + Carbamazepine
嚴重程度: 嚴重
Aripiprazole and Carbamazepine: major interaction.
最後更新
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摘要
Carbamazepine markedly lowers aripiprazole concentrations by enzyme induction, which may cause relapse of psychiatric symptoms.
用白話說明這項交互作用的意義
Aripiprazole and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Carbamazepine belongs to Central Nervous System.
為什麼會發生
Induction of CYP3A4 by carbamazepine increases aripiprazole clearance.
處置方式
Double the aripiprazole dose when carbamazepine is added and monitor response. Reduce it back when carbamazepine is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aripiprazole 的其他交互作用
Carbamazepine 的其他交互作用
常見問題
Can I take Aripiprazole with Carbamazepine?
MediHelp rates the interaction as major. Aripiprazole and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine markedly lowers aripiprazole concentrations by enzyme induction, which may cause relapse of psychiatric symptoms.
How serious is the interaction between Aripiprazole and Carbamazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Double the aripiprazole dose when carbamazepine is added and monitor response. Reduce it back when carbamazepine is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
