藥物交互作用
Arsenic trioxide + Quinidine
嚴重程度: 禁忌併用
Arsenic trioxide and Quinidine: contraindicated interaction.
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摘要
Both drugs prolong the QT interval, and arsenic trioxide is also linked to torsades de pointes and complete AV block. Combined use raises the risk of life-threatening ventricular arrhythmia.
用白話說明這項交互作用的意義
Arsenic trioxide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Quinidine belongs to Anti Parasitic.
為什麼會發生
Additive blockade of cardiac repolarizing potassium currents causing QT prolongation.
處置方式
Avoid the combination and choose a non-QT-prolonging antiarrhythmic. If unavoidable, correct potassium and magnesium and monitor ECG closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Quinidine 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Quinidine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and arsenic trioxide is also linked to torsades de pointes and complete AV block. Combined use raises the risk of life-threatening ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antiarrhythmic. If unavoidable, correct potassium and magnesium and monitor ECG closely.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Artemether / lumefantrine, Chloroquine. The full list is on the Quinidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
