藥物交互作用
Dofetilide + Quinidine
嚴重程度: 禁忌併用
Dofetilide and Quinidine: contraindicated interaction.
最後更新
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摘要
Both drugs prolong cardiac repolarization, and concurrent use raises the risk of torsades de pointes and sudden death. Quinidine may also reduce renal clearance of dofetilide, increasing its exposure.
用白話說明這項交互作用的意義
Dofetilide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
為什麼會發生
Additive potassium channel blockade causing QT prolongation, with possible reduced renal elimination of dofetilide.
處置方式
Do not coadminister; allow adequate washout of the first antiarrhythmic before starting the other, under ECG monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Quinidine 的其他交互作用
Dofetilide 的其他交互作用
常見問題
Can I take Dofetilide with Quinidine?
MediHelp rates the interaction as contraindicated. Dofetilide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong cardiac repolarization, and concurrent use raises the risk of torsades de pointes and sudden death. Quinidine may also reduce renal clearance of dofetilide, increasing its exposure.
How serious is the interaction between Dofetilide and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; allow adequate washout of the first antiarrhythmic before starting the other, under ECG monitoring.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
