藥物交互作用
Artemether / lumefantrine + Ofloxacin
嚴重程度: 嚴重
Artemether / lumefantrine and Ofloxacin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
用白話說明這項交互作用的意義
Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive hERG potassium channel blockade leading to QT prolongation.
處置方式
Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ofloxacin 的其他交互作用
常見問題
Can I take Artemether / lumefantrine with Ofloxacin?
MediHelp rates the interaction as major. Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
