藥物交互作用
Arsenic trioxide + Ofloxacin
嚴重程度: 嚴重
Arsenic trioxide and Ofloxacin: major interaction.
最後更新
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摘要
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and ofloxacin adds further risk. Together they may precipitate life-threatening ventricular arrhythmia.
用白話說明這項交互作用的意義
Arsenic trioxide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Ofloxacin belongs to Anti Bacterial.
為什麼會發生
Additive QT prolongation; arsenic trioxide alters cardiac ion currents and ofloxacin blocks hERG potassium channels.
處置方式
Avoid the combination and choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ofloxacin 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Ofloxacin?
MediHelp rates the interaction as major. Arsenic trioxide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and ofloxacin adds further risk. Together they may precipitate life-threatening ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
