藥物交互作用
Asciminib + Atorvastatin
嚴重程度: 中度
Asciminib and Atorvastatin: moderate interaction.
最後更新
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摘要
Asciminib inhibits OATP1B and BCRP, which participate in atorvastatin hepatic uptake and efflux. Atorvastatin exposure may rise, increasing the risk of myopathy and rhabdomyolysis.
用白話說明這項交互作用的意義
Asciminib and Atorvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asciminib belongs to Oncology; Atorvastatin belongs to Cardiovascular.
為什麼會發生
Inhibition of OATP1B and BCRP transporters by asciminib raises atorvastatin systemic exposure.
處置方式
Monitor for muscle pain, weakness and CK elevation, and consider a lower atorvastatin dose during asciminib therapy.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Atorvastatin 的其他交互作用
Asciminib 的其他交互作用
常見問題
Can I take Asciminib with Atorvastatin?
MediHelp rates the interaction as moderate. Asciminib and Atorvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asciminib inhibits OATP1B and BCRP, which participate in atorvastatin hepatic uptake and efflux. Atorvastatin exposure may rise, increasing the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Asciminib and Atorvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation, and consider a lower atorvastatin dose during asciminib therapy.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
