藥物交互作用
Asenapine transdermal + Carbidopa-entacapone-levodopa
嚴重程度: 嚴重
Asenapine transdermal and Carbidopa-entacapone-levodopa: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Asenapine is a dopamine antagonist and can oppose the effect of levodopa, worsening parkinsonian symptoms. Additive sedation and orthostatic hypotension can also occur.
用白話說明這項交互作用的意義
Asenapine transdermal and Carbidopa-entacapone-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Pharmacodynamic antagonism at dopamine D2 receptors plus additive sedative and hypotensive effects.
處置方式
Avoid in Parkinson's disease where possible; if an antipsychotic is needed, use quetiapine or clozapine and monitor motor function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbidopa-entacapone-levodopa 的其他交互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 禁忌併用
- Carbidopa-entacapone-levodopa + Phenelzine 禁忌併用
- Carbidopa-entacapone-levodopa + Selegiline transdermal 禁忌併用
- Carbidopa-entacapone-levodopa + Tranylcypromine 禁忌併用
- Amisulpride + Carbidopa-entacapone-levodopa 嚴重
- Carbidopa-entacapone-levodopa + Chlorpromazine 嚴重
常見問題
Can I take Asenapine transdermal with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as major. Asenapine transdermal and Carbidopa-entacapone-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asenapine is a dopamine antagonist and can oppose the effect of levodopa, worsening parkinsonian symptoms. Additive sedation and orthostatic hypotension can also occur.
How serious is the interaction between Asenapine transdermal and Carbidopa-entacapone-levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson's disease where possible; if an antipsychotic is needed, use quetiapine or clozapine and monitor motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
