藥物交互作用
Carbidopa-entacapone-levodopa + Isocarboxazid
嚴重程度: 禁忌併用
Carbidopa-entacapone-levodopa and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
用白話說明這項交互作用的意義
Carbidopa-entacapone-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines with additional COMT inhibition
處置方式
Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Carbidopa-entacapone-levodopa 的其他交互作用
- Carbidopa-entacapone-levodopa + Phenelzine 禁忌併用
- Carbidopa-entacapone-levodopa + Selegiline transdermal 禁忌併用
- Carbidopa-entacapone-levodopa + Tranylcypromine 禁忌併用
- Amisulpride + Carbidopa-entacapone-levodopa 嚴重
- Asenapine transdermal + Carbidopa-entacapone-levodopa 嚴重
- Carbidopa-entacapone-levodopa + Chlorpromazine 嚴重
Isocarboxazid 的其他交互作用
常見問題
Can I take Carbidopa-entacapone-levodopa with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Carbidopa-entacapone-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-entacapone-levodopa and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Phenelzine, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-entacapone-levodopa page.
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