藥物交互作用
Carbidopa-entacapone-levodopa + Chlorpromazine
嚴重程度: 嚴重
Carbidopa-entacapone-levodopa and Chlorpromazine: major interaction.
最後更新
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摘要
Chlorpromazine blocks dopamine receptors and can markedly worsen parkinsonism, negating the benefit of levodopa. Levodopa may also reduce the antipsychotic effect.
用白話說明這項交互作用的意義
Carbidopa-entacapone-levodopa and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
為什麼會發生
Pharmacodynamic antagonism through D2 receptor blockade.
處置方式
Avoid chlorpromazine in patients taking levodopa. Use quetiapine or clozapine if an antipsychotic is needed, and monitor motor function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbidopa-entacapone-levodopa 的其他交互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 禁忌併用
- Carbidopa-entacapone-levodopa + Phenelzine 禁忌併用
- Carbidopa-entacapone-levodopa + Selegiline transdermal 禁忌併用
- Carbidopa-entacapone-levodopa + Tranylcypromine 禁忌併用
- Amisulpride + Carbidopa-entacapone-levodopa 嚴重
- Asenapine transdermal + Carbidopa-entacapone-levodopa 嚴重
Chlorpromazine 的其他交互作用
常見問題
Can I take Carbidopa-entacapone-levodopa with Chlorpromazine?
MediHelp rates the interaction as major. Carbidopa-entacapone-levodopa and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine blocks dopamine receptors and can markedly worsen parkinsonism, negating the benefit of levodopa. Levodopa may also reduce the antipsychotic effect.
How serious is the interaction between Carbidopa-entacapone-levodopa and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chlorpromazine in patients taking levodopa. Use quetiapine or clozapine if an antipsychotic is needed, and monitor motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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