藥物交互作用
Atazanavir + Cabazitaxel
嚴重程度: 嚴重
Atazanavir and Cabazitaxel: major interaction.
最後更新
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摘要
Atazanavir is a strong CYP3A4 inhibitor and can markedly raise cabazitaxel exposure. This increases the risk of severe neutropenia and other toxicities of cabazitaxel.
用白話說明這項交互作用的意義
Atazanavir and Cabazitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Cabazitaxel belongs to Oncology.
為什麼會發生
Atazanavir inhibits CYP3A4-mediated metabolism of cabazitaxel.
處置方式
Avoid concomitant use of strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, consider reducing the cabazitaxel dose and monitor blood counts closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cabazitaxel 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Cabazitaxel?
MediHelp rates the interaction as major. Atazanavir and Cabazitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can markedly raise cabazitaxel exposure. This increases the risk of severe neutropenia and other toxicities of cabazitaxel.
How serious is the interaction between Atazanavir and Cabazitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of strong CYP3A4 inhibitors with cabazitaxel. If unavoidable, consider reducing the cabazitaxel dose and monitor blood counts closely.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Cabazitaxel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
