藥物交互作用
Atazanavir + Esomeprazole
嚴重程度: 嚴重
Atazanavir and Esomeprazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Atazanavir needs an acidic stomach to dissolve, so esomeprazole can markedly reduce its levels. This may lead to virologic failure and development of resistance.
用白話說明這項交互作用的意義
Atazanavir and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Esomeprazole belongs to Gastrointestinal Tract.
為什麼會發生
Higher gastric pH decreases atazanavir solubility and absorption.
處置方式
Avoid PPIs in treatment-experienced patients. In treatment-naive patients on ritonavir-boosted atazanavir, keep the PPI dose to an omeprazole 20 mg equivalent, give it about 12 hours before atazanavir, and monitor viral load.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Esomeprazole 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Esomeprazole?
MediHelp rates the interaction as major. Atazanavir and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic stomach to dissolve, so esomeprazole can markedly reduce its levels. This may lead to virologic failure and development of resistance.
How serious is the interaction between Atazanavir and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients. In treatment-naive patients on ritonavir-boosted atazanavir, keep the PPI dose to an omeprazole 20 mg equivalent, give it about 12 hours before atazanavir, and monitor viral load.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
