藥物交互作用

Esomeprazole + Rilpivirine

嚴重程度: 禁忌併用

Esomeprazole and Rilpivirine: contraindicated interaction.

最後更新 13 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Esomeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.

用白話說明這項交互作用的意義

Esomeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Esomeprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.

證據等級: High

為什麼會發生

Elevated gastric pH reduces absorption of oral rilpivirine, which needs an acidic environment.

處置方式

Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Esomeprazole 與 Rilpivirine 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Esomeprazole with Rilpivirine?

MediHelp rates the interaction as contraindicated. Esomeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Esomeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.

How serious is the interaction between Esomeprazole and Rilpivirine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).

What other medicines interact with Esomeprazole?

MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Acalabrutinib, Atazanavir. The full list is on the Esomeprazole page.

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摘要