藥物交互作用
Atazanavir + Lurasidone
嚴重程度: 禁忌併用
Atazanavir and Lurasidone: contraindicated interaction.
最後更新
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摘要
Atazanavir, a strong CYP3A4 inhibitor (especially when boosted), markedly increases lurasidone exposure. Lurasidone labeling contraindicates concurrent use with strong CYP3A4 inhibitors because of risk of excessive adverse effects such as akathisia, sedation and extrapyramidal symptoms.
用白話說明這項交互作用的意義
Atazanavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Lurasidone belongs to Central Nervous System.
為什麼會發生
Atazanavir inhibits CYP3A4, the main metabolic pathway of lurasidone.
處置方式
Avoid the combination; choose an antipsychotic less dependent on CYP3A4 or an alternative antiretroviral.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lurasidone 的其他交互作用
Atazanavir 的其他交互作用
常見問題
Can I take Atazanavir with Lurasidone?
MediHelp rates the interaction as contraindicated. Atazanavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir, a strong CYP3A4 inhibitor (especially when boosted), markedly increases lurasidone exposure. Lurasidone labeling contraindicates concurrent use with strong CYP3A4 inhibitors because of risk of excessive adverse effects such as akathisia, sedation and extrapyramidal symptoms.
How serious is the interaction between Atazanavir and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an antipsychotic less dependent on CYP3A4 or an alternative antiretroviral.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Carbamazepine, Clarithromycin. The full list is on the Lurasidone page.
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